Twenty four patients with hepatocellular carcinoma who refused surgery or had unresectable tumor ranging 2.5 to 8.0 cm in size were treated with intrahepatic arterial injection of iodine-131-labeled iodized oil (I-131 Lipodol) in an attempt to achieve internal radiation of tumor. 555-2,220 MBq in 3-8 ml of I-131 Lipiodol was injected into the hepatic artery or proximal to the tumor feeding vessel depending on the tumor size. Tumor size reduction was observed in 88.9% of tumor smaller than 4.0 cm in diameter, 65.5% between 4.1 to 6.0 cm, and 25.0% of larger than 6.1cm, respectively. The tumor size reduction was corresponded to the gradual drop of serum AFP levels, decreased uptake on gallium-67 scintigraphy, and devascularization on follow-up angiography. Tumors having significant A-V shunts revealed further tumor growth. Adverse reactions from the treatment include fever, mild abdominal pain, nausea and elevation of transaminases. These have been mild and well-tolerated by the patients. This method was able to provide long term local control without complications related to thyroid, lung, GI tract and bone marrow.
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机译:对二十四例拒绝手术或肿瘤大小在2.5至8.0 cm的不可切除肿瘤的肝细胞癌患者,通过肝内动脉注射碘131标记的碘化油(I-131 Lipodol)进行治疗,以期实现肿瘤的内部放射治疗。根据肿瘤大小,将3-8 ml I-131 Lipiodol中的555-2,220 MBq注入肝动脉或靠近肿瘤供血血管。在直径小于4.0厘米的肿瘤中,有88.9%的肿瘤缩小,在4.1到6.0 cm之间的肿瘤中有65.5%的肿瘤,在大于6.1 cm的肿瘤中有25.0%的肿瘤。肿瘤大小的减少与血清AFP水平的逐渐降低,镓67闪烁显像仪的摄取减少以及后续血管造影术中的血运减少有关。具有明显A-V分流的肿瘤显示出进一步的肿瘤生长。该治疗的不良反应包括发烧,轻度腹痛,恶心和转氨酶升高。这些是轻度的,并且患者很好地耐受。这种方法能够提供长期的局部控制,而没有与甲状腺,肺,胃肠道和骨髓有关的并发症。
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